Gli oli di semi sono infiammatori?! (Le *prove* che nessuno mostra)

“Gli oli di semi sono infiammatori!” secondo ogni blog e podcast. Ma cosa dice la scienza? L'evidenza su 9 diversi oli di semi, oli di semi riscaldati e variabilità genetica. Uno sguardo completo agli oli di semi e alle infiammazioni e a tutte le prove che non ti sono mai state mostrate.

Gli oli di semi sono infiammatori?

1. Olio di semi sull'infiammazione
2. Olio di semi riscaldato

L'olio vegetale è infiammatorio? Solo gli oli di semi sono infiammatori? Dipende da omega6, acido linoleico?

olio di semi di lino non infiammatorio. ricco di omega3, può essere antinfiammatorio
olio di canola: il CRP non ha cambiato

grassi saturi rispetto agli omega 6. sostituito i grassi saturi con quelli insaturi (colza e girasole). nessun cambiamento nei marcatori infiammatori<br/>
uno studio ha confrontato la canola con l'olio d'oliva, ha riscontrato una riduzione della PCR sia sulla colza che sull'olio d'oliva
simile a Olio di semi di lino. antinfiammatorio?

~1 cucchiaio di olio di girasole al giorno. olio raffinato, trattato con prodotti chimici e riscaldato, non spremuto a freddo. nessuna modifica significativa al CRP

“n-6 PUFA può agire come antinfiammatorio”

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Riferimenti:
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100 Risposte a “Gli oli di semi sono infiammatori?! (Le *prove* che nessuno mostra)”

  1. Wow this must have taken alot of time, well done. I'm kind of dissapointed that so few studies specified whether the oil was refined or not, and that there wasnt many comparing seeds to refined seed oils. I think thats where the interesting part lies. I'm worried that most of the positive molecules you would find in these seeds are lost during the refining process, and removing them from their protective shell exposes them to oxidation. Really hope you are going to make all those other videos you mentioned. Oxidation, cancer, and heart disease (that one is definitely contentious). If you're not already knee deep in the research, Martin Grootveldt has some really interesting research on frying with PUFA rich oils.

  2. wait, arent you drawing a conclusion solely based on inflamation? What about endotelial function? weight gain? Are these studies done really reflecting a lifetime of multiple times a day intake of oils/fried meals?

  3. Let’s get into Glyphosate and what it does for the gut microbiome. We are hearing it isn’t detrimental to the human being but it can be detrimental to good gut bacteria. It would be great to know where glyphosate is used in farming and harvesting and how deeply it gets spread throughout the food chain ultimately into the stomachs of humans.

  4. A year and a half ago, I went keto (mostly, definitely low carb), cutting out all oils, except olive, avocado, and coconut, using a ton of saturated fats from bacon grease for most of my cooking. I've had great results with this change in my diet (losing 70 lbs in 6 months), but am now re-evaluating the long-term viability of staying heavily low carb and focusing on saturated fats. Sugary, heavily-processed junk foods are gone forever. However, due to the content of your videos, I'm altering other aspects of my diet. I think that I will continue to avoid the high-omega-6 oils as much as possible, but I'll be stop being scared of them. I think that I'll also start re-introducing some grains into my diet, too, and will go look to see if you've made a "Are Grains Really Bad for You" video. Great content! Much appreciated!

    I'm kind of curious. You've obviously put a lot of time/effort into videos like this. Do you ever publish any of your meta analyses of meta analyses?

  5. I have a strange feeling that no one will ever prove that God does not exist by using the Bible. but that's maybe just me

  6. Thanks for this. I like soybean oil because it's affordable, has a neutral flavor, and has a high smoke point, so I use it for pan-searing cuts of meat and stuff, and I was confused when someone was suddenly warning me about all the dangers of soybean oil and that I should only be using extra virgin olive oil for everything. Olive oil is a lot more expensive and has a strong flavor, so I'd rather not use it. Glad to know the concern is overblown.

  7. Thank you. Is it possible you could perhaps co-host/collaborate with one or more of these YouTube "doctors" who promote saturated fat and revile seed oils? I would love to see two of you presenting evidence and discussing/debating what the evidence means, and why some evidence should be given more weight than other evidence. I dislike one sided arguements. I grew up in a time when news comentators always had a cohost so that both points of view could be presented by their proponents to give people a clearer picture and allow people a fuller understanding to make decissions on. I miss that. I fear "The Dangers of The Single Story".

  8. wow, fascinating look Gil.
    Irony is your last few vids make it look like you will be recommending SAD diet, processed food diet

  9. This is the first time I feel like giving super thanks on YouTube since the information you provided is much better summarised then many dietary books. Thank you so much! It also sets a new bar for dietary claims from other sources, unless I see the same level of details I won't automatically believe it.

    Can you maybe add an option to send you a super thanks?

  10. I love your honesty. Most of us simply want to manage our health. Getting clear unbiased information not influenced by current food fashion is sometimes hard.

  11. I could not thank you more for this highly informative video , it has addressed all my questions and worries about seed oil, 👍👍👍👍👍👍👍

  12. I believe that any oil that is extracted mechanically and not with chemistry should be OK. But when industry would like to get more yield from the seeds then the problem starts. I saw non virgin olive oil and was on a bottle 1$ compared to 15$ for a premium one. This probably should be less healthy. In general, all of those ingredients cheap with long shelf life combined together are a health issue. Statistically you can see when and where heart diseases are on a rise and what is this demography consuming on a long run. Also, our body is trying to be in balance. And similarly, also our inflammatory markers. So could happen that those are rising only when a balance in a metabolic process is ruined.

  13. Another great content. Thank you very much.

    I know it's just been released, but we are waiting your review of What The Health. 👀

  14. I wonder then whether the inflammatory effect depends on whether the oils are combined with starches/carbs, activating the Randle cycle? Vegetables, proteins with fat aren't an activating combination.

  15. could you explain why animals fed unsaturated vegetable oils get fat, diabetes and fatty liver while ones fed coconut oil get none of the above? the obesity epidemic in america mirrors pufa consumption.

  16. I’m in the camp that if it’s not clearly going to be healthy, I don’t need it. It’s not a necessary part of my diet, and they appear to be worked into all processed foods, and in an effort to reduce my processed food intake as much as possible these two go together well. The day someone starts attacking a whole unprocessed food diet then I’m just throwing in the towel

  17. Wasn't sure what I was going to get when clicking on this video, but it is very well put together and has links to references in the description. Quite informative, well done!

  18. This just proves how neurotic and jaded so many health "experts" are and give bad advice..just like the MSG hysteria..its never been proven that it's bad for you..the only health advice that's valid is moderation.
    All these health gurus that get caught up in demonizing one food or substance need to get a life…

  19. I’ve been worried about my taking Black Seed Currant Oil because of possible inflammation. But it’s made a HUGE difference in my menopause symptoms. I don’t even have to take e-trace anymore. My OB had even suggested surgery. It blows my mind that women have surgery annually to deal with these issues, but without the BSCOil’s, I was in pain all the time. I feel better now about my taking BSCO. Thanks Dr. Gil!

  20. What if the right question is not whether seed oils are inflammatory, but rather if a diet with a high omega 6/3 ratio over long periods is inflammatory. You give good evidence that high omega 6 oils in and of themselves are not, but what is the consequence of prolonged exposure to a high 6/3 diet over time? Seems to me that the net result could be a chronic omega 3 deficiency as 6 "crowds out" 3 which could lead to chronic inflammatory response.

  21. Well done. Can you please do this topic again but on *gut microbiome health*? I would love to see the data showing gut health before, during and after regular seed oil consumption and whether refined or unrefined makes a significant difference in that manner. Thank you for your videos, always professional and to the point 🙂

  22. One of the main concerns with some of these highly processed oils is byproducts that they can't completely remove. For instance, some of them go through an extreme heating cycle, but are then treated to remove the rancid smell/flavor, but is the end product actually pure or does it still have oxidation byproducts from that heating?

    I'd also agree, people shouldn't conflate clearly unhealthy processed foods with everything in them. But I don't fault people for avoiding processed foods since there's such a strong correlation between their advent and gaining popularity in our diet and the prevalence of dozens of terrible illnesses. There's also some older studies that found a significant difference after 7 years that didn't appear early on, meaning there's the question of whether these shorter studies would ever find an issue that takes decades to develop. "The science" isn't absolute knowledge of how things work, and I really wish people wouldn't pretend like that's what it is.

  23. You mentioned replacement as a major factor in analyzing these studies in an earlier video about the literature on saturated fat, isn't it also relevant to consider here? Given that participants are taking a substantial amount of calories from these experiments (500 calories?!) we should definitely expect them to also eat less of their normal diet. These oils are already present in a lot of common food products which might be the majority of what participants are replacing to result in "no significant change" from their pre-existing background inflamation, a similar critique you outlined in the saturated fat video.

    Additionally, we know that there needs to be a a 1:1 to 2:1 ratio of omega-6 to omega-3 for the best health outcomes, which flaxseed has the best balance of on its own. I would have liked to see those seed oil and heated oil experiments also supplemented with the proper omega-3 balance and have them compared to the flaxseed oil results. The omega-6/omega-3 balance of those seed oils is arguably easy to fix with proper supplementation, so the next major point to address in the popular criticism is the presence of additional unremovable inflamation factors due to heat and processing.

  24. Thank you so much for videos. The work of deciphering all of scientific studies out there on general health topics is very important. The media likes to only interested in feeding people junk science for ratings. Kudos to you for helping people navigate through this!

  25. I have been arguing that the oil in itself is not the problem, but underlaying health conditions.
    If you have allergy, you might experience a stronger inflammation response.
    This is on personal anecdotal evidence though.
    Having lived in a moldy house for a few years in my early teens, I developed a higher sensitivity to dust particles.

    This was simply discomfort but at a point I change from canola (17%) to sunflower (54%), I became hypersensitive.
    I did not discover this however for some time, I used Keto as elimination diet and only found that products containing sunflower oil would cause a spike.

    But this might not be related to the sunflower oil at the end, just like how we can't eat 45-65% of the grains grown here in Norway due to mold poisons.
    So it can simply be the quality of the oil.

    But my concern with some of the seed oils is the extent of use.
    This ofc varies by country but here in Norway, some elderly use hardened canola margarine for cooking, "soft" hardened canola on the bread and in resent years a variety of products now use sunflower oil as a replacement for palm oil (biscuits) peanut oil (potato chips).
    It is simply a concern of how much, as it seems some individuals are going to have their entire fat intake from refined seed oils.

    I personally use butter and olive oil in general as other products like mayonnaise contains all the canola oil your body ever needs.

    On the point of poisons.
    Food infection is something you get if you consume food that contains to much bacteria that is "hostile" to your guy bacteria.
    Food poisoning is something you get if that bacteria produce poison OR if the food you ate though heated was covered by one that left the poison on the food.

    So if you ever use almond oil, just remember that if the quality of the producer is bad, all it takes is a single bitter almond.

  26. Not sure why people get so passionate about this subject. I suspect its because there is always a conspiratorial aspect added to everything nutrition.

  27. Great work in this video – congratulations 🙂 Thanks for all the hard and meticulous work along with references. I wish more videos for the general population on health topics took your approach.

  28. So, basically we have zero clue what are the dietary causes behind heart disease. It's not vegetable oils. It's not cholesterol. It's not dietary fat. Why are people dying of heart attacks at 40 with perfectly clear arteries? For years we are told that fat is the culprit. Now studies are showing that saturated fat is neutral. And now we are told that these inflammatory oils aren't inflammatory after all. So, what is the mechanism behind heart disease? Do we really have ZERO clue in 2022?

  29. My grandma made Rösti (form of hash browns in Switzerland), she made that with extra fatty bacon and butter. With Rösti we had sausage salat where cheese tomatos cucumbers vinigar and onions are added. In the end she would always pour a ton of sunflower oil over it 😃😄 And she lived very well to 96. So what….

  30. You should have also showed other fats, butter, cheese etc animal fats. Are they inflammatory? Seems there were one paper that said something about this, but was a study about cholesterol levels.
    But overall, good debunking of this nonsense myth about "seed oils". Its only meant to be the replacement "evil" for cholesterol.

  31. Recommend checking out : "Omega-6 fatty acids do not promote low-grade inflammation"

    November 13, 2017

    University of Eastern Finland
    It explains why we though that omega 6 would be inflammatory, and also shows the opposite is true. Omega 6 LA is anti inflammatory. And that makes sense, considering its an essential fatty acid. Why would an essential fatty acid be pro inflmatory?

  32. Thank you very much for the content. Could you please consider uploading a similar video on animal fats like lard, butter, etc.? What happens when someone cooks with these fats and keeps their corresponding calorie intake below the maximum advised level (10%), especially concerning inflammation or other long-term health issues? I have found papers on negative effects of those fats but they show high levels of consumption and, of course, there are other variables that make it confusing for someone without expertise. I would immensely appreciate your insights. Best wishes for you and the rest of the team.

  33. This is my second video recommended by YouTube from this channel. Currently I only eat meat, eggs and avocado. I use pork and chicken fat to cook my food. I'm afraid of vegetable oils because I was suffering inflammation 8 months ago. Long story short I don't anymore after eliminating carbohydrates except for the avocado.

  34. This makes me wonder how the heck they came up with the Omega 6 to 3 ratio hypothesis.

    Something ain't right when the medical field have such varying opinions and "results" from research on nutrition.

    I for sure am biased and strongly believe that if you can't make it by hand with simple tools like sticks and stones or find it in it's pure form in nature. Then it can't possibly be good for you in the long run.
    It's all about balance. Everything is.

  35. I've always heard most oils are fine, but shelf life is important due to oxidation. Canola oil for example, is very prone to oxidation whereas something like tallow/coconut oil is more stable. As far as I've been able to tell, it's difficult to measure reactive-oxygen-species (ROS) except in vitro (Ref. 1). Is it possible that difficult to measure biomarkers like ROS could be important to this puzzle? In some animal studies, canola oil appears to increase oxidative stress and reduce life span (Ref. 2)

    I am curious if you have seen any data in humans about the effects of different oils increasing oxidative stress? Can we glean whether or not a food is healthy based on inflammatory markers alone? I don't know these things.

    Watched the whole thing. Thanks for the information.

    1. Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494111/)
    2. The effect of short-term canola oil ingestion on oxidative stress in the vasculature of stroke-prone spontaneously hypertensive rats (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215974/)

  36. 1. At 21:16 you were talking about a soybean oil, but the study as seen on screen was about"Camellia oil." Do camellias even make a seed? I had never even heard of camellia oil. 2. I would like to see the comparison of each of the seed oil as compared to animal fat. 3. Each study compared a different two oils which may leed to doubts or question. 4. Some mention of controling for extraneous factors, such as what else were the subjects consuming along with the oils being studied. Even with all that said, I can certanly appreciate the time and effort you put into this comparative analysis, and you did a great job of presenting data to test whether or not seed oils are inflamatory. THANKS for that!

  37. Olive oil and Coconut oil can be cold pressed to produce them, but all seed oils have to use a lot of chemicals and heat to produce them. Seed oils are oxidized more the longer you leave them standing. ~ Omega 3 from plant (ALA) is not the same as animal Omega 3 (DHA and EPA ). Our body can not use ALA and it is not easy to be converted to DHA and EPA , only about 5% can be successfully converted.

  38. Finally someone who can sort out the fact from the fiction. I always wanted to know about heated seed oil effects and now I know it is safe to consume cheaper seed oils rather than paying for premium virgin olive oil.

  39. Thanks for the content. But do we know if seed oils are harmful in other ways, even when inflammation isn't present? There seem to be some studies that indicate they could be deleterious with regards to developing diabetes. Wouldn't this be possible even in the absence of inflammation?

  40. So I guess my question is just what does cause heart disease then if it's not saturated fat and it's not omega 6 fats etc. etc? It has to be something if heart disease was almost absent until after the 1930's

  41. Wow Gil, the amount of reading and researching you have done on this topic is very impressive. I wonder how long it took you to put this video together, thanks very much for your hard work!

  42. This is why people "question the science" and want to see the hard data. Always ask for the data and never blindly accept the conclusions.

  43. I would suggest that a long term very large double blind studies, by both european and USA funded studies be done with soybean oils and with lecithin and emulsifiers, very long term studies on people with bipolar, schizophrenia, and autism spectrum disorders, the oils in large part DO NOT contain the emulsifiers, and lecithins affects on mood, elimination of the lecithins ( including and importantly soy lecithin) entirely from controlled group . To repeat, the studies you point to cover the oils, which have had the lecithin REMOVED.

  44. Human societies have been cooking with seed oils for centuries. The whole debate is dumb. ALL oils are inflammatory and should be restricted in the diet. Eat more plant foods, less saturated fat, less salt, less sugar. It’s actually really easy for people to have a healthy diet when they spend more time eating healthy and less time splitting hairs on the internet.

  45. Sad Paul saladino noises
    edit: what about the other stuff people say about PUFA? there is the claim that they raise oxLDL since PUFA is more succeptable to oxidation and when comsuming higher amounts of PUFA LDL is comprised of them. Also there is the claim (y'know, saladino is onto this) that if cell membranes are made out of PUFA they are more succeptable to damage. And the 3rd claim is, that PUFA themselves oxidize and become lipid peroxides which are toxic. Would love to see something about these things too, since i believe that you can debunk these claims very easily (i cant).

  46. Inflammation with oils is not the real problem. The issue was with arteries and heart with ensel keys 9 country study.
    It's oxidation and high heat as well as refined vs unrefined(chemicals an high heat). I thought inflammation was associated with flour an sugar. Hmmm ..
    Lower heat cooking, Better oils, and everyone is diff due to age, lifestyle and what you were born with.
    More veg, less meat and mindful of amounts of oil whole grains and read labels for chemicals we do not want in our food. Red dye # 4 is not something we should want unless your trying to make money on something that has to have a red hue look to it.

  47. I don't really care what you say, I like sesame seed oil. That's about the only seed oil I can think of. Is avocado oil a seed oil? Then I like that too. What about walnut oil? Oh yeah, and I like Flax Seed oil … but you cannot really cook with it, but it has a good taste and a lot of Omega-3's.

  48. What about butter? All my life I heard about how butter was so terrible for people. Is it true? Does it clog our veins and arteries? Is there a safe level and if so what is it?

  49. The food industry sells soybean and corn oils more in liquid form, and not in baked foods, because a baked food sitting in a package would be exposed to oxygen for a longer period of time. They tend to use canola, sunflower oil, etc for baked products.

  50. After you review the metanalysis-style papers, maybe go deeper into a couple of papers that support one view or another? That way, you can answer many of the questions your audience has about these studies. For example, the medical history of the trial participants, their regular dietary habits, etc., are highly critical when drawing conclusions. Also, it might be worth discussing the effects of various additives that manufacturers add to processed oils to stabilize them and prevent oxidation.

  51. Does this mean that eating fried foods does not raise inflammation? I thought eating fried foods was unhealthy. If it is unhealthy, then how is that degradation of our health measured if not by inflammatory markers?

  52. Oh. If only your kind of people are the ones the algorithm picks up instead of those "nutritionists" and "MDs" who just love to fearmonger on seed oils, glyphosates, and high-fructose corn syrup (it's literally fructose and glucose, just like your damn table sugar). The worst part is that people are actually buying their idiocy and they now have millions of people that back them up on their baseless claims.

  53. Love your videos! Being in the healthcare space and with a recent trend in lifestyle interventions, these are the types of topics and summaries that we need! I’d like to see a topic around different oils and their impact on weight gain, and with an interest more in the volume of fried foods that one eats.

  54. hsCRP is not the indicator you should look at to evaluate the problem of seed oils. You should look at fasting insulin instead. And it takes years for the damage to the metabolism to occur, not just weeks.

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